Buy Tryptamines

Tryptamine is the indolamine metabolite of the essential amino acid tryptophan. [2] [3] The chemical structure is defined by an indole—a fused benzene and pyrrole ring—and a 2-aminoethyl group at the second carbon (third aromatic atom, the first being the heterocyclic nitrogen). [2] The structure of tryptamine is shared by certain aminergic neuromodulators such as melatonin, serotonin, and bufotenin, as well as psychedelic derivatives such as dimethyltryptamine (DMT), psilocybin, psilocin, and others. [4] [5] [6] Tryptamine has been shown to activate trace amine-associated receptors expressed in mammalian brain. It also controls the activity of the dopaminergic, serotonergic, and glutamatergic systems. [7] [8] Symbiotic bacteria in the human gut convert dietary tryptophan to tryptamine, which activates 5-HT4 receptors and regulates GI motility. [3] [9] [10] A number of tryptamine-derived drugs have been developed to treat migraines, and trace amine-associated receptors are being investigated as a potential treatment target for neuropsychiatric disorders. [11] [12] [13]