Tryptamine is the indolamine metabolite of the essential amino acid tryptophan.   The chemical structure is defined by an indole—a fused benzene and pyrrole ring—and a 2-aminoethyl group at the second carbon (third aromatic atom, the first being the heterocyclic nitrogen).  The structure of tryptamine is shared by certain aminergic neuromodulators such as melatonin, serotonin, and bufotenin, as well as psychedelic derivatives such as dimethyltryptamine (DMT), psilocybin, psilocin, and others.    Tryptamine has been shown to activate trace amine-associated receptors expressed in mammalian brain. It also controls the activity of the dopaminergic, serotonergic, and glutamatergic systems.   Symbiotic bacteria in the human gut convert dietary tryptophan to tryptamine, which activates 5-HT4 receptors and regulates GI motility.    A number of tryptamine-derived drugs have been developed to treat migraines, and trace amine-associated receptors are being investigated as a potential treatment target for neuropsychiatric disorders.