What is 4-AcO-MET?

4-Acetoxy-N-ethyl-N-methyltryptamine (also known as 4-AcO-MET, Metacetin, and Azomet) is a novel psychedelic substance of the tryptamine class. When administered, members of this group produce psychedelic effects similar to psilocybin. It is structurally related to psychedelic tryptamines such as 4-AcO-DMT, 4-AcO-DET, and 4-AcO-MiPT.

4-AcO-MET has a similar structure to 4-HO-MET, for which it is thought to act as a prodrug.

4-AcO-MET is found on occasion in pressed pills sold on the streets of northern Switzerland under the names “Acomet” or “Azomet.”

There is little information available about the pharmacological properties, metabolism, and toxicity of 4-AcO-MET, and it has a limited history of human use. It is available as a research chemical online. When using this substance, it is strongly advised to use harm reduction practices.

Chemical Properties

4-AcO-MET, also known as 4-Acetoxy-N-methyl-N-ethyltryptamine, is a tryptamine-class synthetic indole alkaloid molecule. The core structure of tryptamines is a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-AcO-MET has an acetoxy (AcO) functional group CH3COO substituted at R4 of its indole heterocycle. It also has a methyl group and an ethyl chain attached to the tryptamine backbone’s terminal amine RN (MET). 4-AcO-MET is the N-substituted ethyl homolog of 4-AcO-DMT and an acetate ester analog of 4-HO-MET.

Pharmacological effects

The psychedelic effects of 4-AcO-MET are thought to be due to its partial agonist activity at the 5-HT2A receptor. However, the role of these interactions and how they result in the psychedelic experience remains a mystery.

Although human studies on the metabolic fate of this drug are lacking, it is also hypothesized that this compound is quickly hydrolyzed into the free phenolic 4-HO-MET. This would explain a somewhat similar experience in their subjective effects. This is similar to how 4-AcO-DMT is thought to be deacetylated to 4-HO-DMT during first pass metabolism and subsequent passes through the liver.

Some of the most commonly reported effects are:

• Sedation
• Spontaneous physical sensations
• Changes in felt bodily form
• Analysis enhancement
• Conceptual thinking
• Delusion
• Autonomous voice communication
• Ego death
• Emotion enhancement
• Perception of interdependent opposites
• Immersion enhancement
• Increased music appreciation
• Memory suppression
• Novelty enhancement
• Personal bias suppression
• Thought acceleration
• Thought connectivity
• Thought loops
• Time distortion
• Unity and interconnectedness
• Wakefulness
• Enhancements
• Distortions
• Hallucinations
• Colour enhancement
• Pattern recognition enhancement
• Visual acuity enhancement
• Distortions
• Drifting.
• After images
• Colour shifting
• Environmental patterning
• Scenery slicing
• Symmetrical texture repetition
• Tracers
• Transformations
• Internal hallucination

Potential Side Effects

• Muscle contractions
• Muscle relaxation
• Excessive yawning
• Watery eyes
• Olfactory hallucination
• Pupil dilation
• Runny nose
• Increased salivation
• Teeth grinding
• Nausea

Legality

4-AcO-MET is classified as illegal in:

• Germany
• Switzerland
• United Kingdom

Product Specifications:

Product Name: 4-AcO-MET fumarate pellets

Other Name(s): 4-acetoxy-N-methyl-N-ethyltryptamine fumarate

CAS: 246-87-2

Chemical formula: C15H20N2O2

Molar mass: 260.337 g·mol−1

Active ingredient: 4-AcO-MET fumarate (20mg)

Other ingredients: MCC, colloidal silicon dioxide, sodium starch glycolate, sodium stearyl fumarate, E127